Research @ NIPER Guwahati

NIPER, GUWAHATI conducts research in different areas of pharmaceutical sciences keeping in view the national and local needs.

Pharmacology and Toxicology

Study in the field of Molecular Hematology to observe the molecular details in various diseases like Multiple Myeloma, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Myodisplastic syndrome.

Protective effect of Carissa carandas against cyclophosphamide-induced toxicity

Evaluate the effect of Naringenin and Crocetin on cyclophosphamide-induced testicular toxicity.

Studies on anti-tumor activity of various plants available in the North East region Effect of Ocimum sanctum in experimental diabetic neuropathy.

Anti-inflammatory activity of Morabulus jalepa in acute and chronic models of inflammation in rats.

Effect of Green tea polyphenols on the pharmacokinetics of Paclitaxel.

Evaluate anti-inflammatory activity of Hibiscus rosa sinensis in rats.

Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice.

Studies on Neurodegenerative diseases like Parkinson’s, Alzheimer’s etc.

Pharmacological studies of various anti cancer agents and plant extracts.

Pharmacological studies in depression.

Biotechnology

Molecular genomics and expression of various targets in Ischemia Stroke disorder etc.

Pharmacogenomics study in Diabetes, use of drugs like clopidogrel and its pharmacogenomic approaches.

Investigation in Molecular pathophysiology of various targets in Neuropathic pain and its future treatment.

Study in the field of Proteomics to develop various target drugs for therapeutic approaches.

Development of synthetic riboswitches to suppress gene expression in case of various life-threatening diseases.

Development of deoxyribozymes, which can degrade RNA of various oncogenes. Generation of various novel protein coding sequences, which can be further developed as biopharmaceuticals.

Suitability of G-quadruplexes as gene regulation tool in cancer and other diseases.

Directed evolution of therapeutic proteins for enhanced activity and least immunogenicity.

Pharmacy Practice

Adverse Drug Reaction (ADR) monitoring

Drug Drug Interaction (DDI) studies

Drug utilization

Pharmacovigilance studies

ADR monitoring of Anti-TB therapy

Pharmaceutical Analysis

Analytical and bioanalytical method development and validation.

Pharmacokinetic studies of drugs and metabolites.

Identification and characterization of impurities in drug substances.

Forced degradation studies and characterization of degradation products.

Short-term/accelerated, mid-term and long-term stability testing of formulations.

Pre-formulation (physicochemical parameters & excipient compatibility) studies.

Chemical characterization of biomarkers in herbal products.

Pharmaceutics

Dosage form design, development, optimization and evaluations for BCS-II & III drugs

Micro-and nanotheragnosis concepts for the early detection and treatment of malignant diseases and other life-threatening diseases

Eradication of biofilm-producing microorganisms from the surfaces of implanted or inserted medical devices into human body

Ligand anchored lipid/polymer-mediated nanoarchitectonics

Pharmacoengineering to fight against neglected diseases

3D Engineering & Printing Technology

Drug(s)-in-adhesive matrix/reservoir type transdermal therapeutic systems

Nanomedicines for organ/lymphatic delivery with deep molecular insights

Extrusion based biofilaments processing for fused-filaments applications

Translational cutting-edge pharmaceutical research & development