Research at NIPER-Guwahati

NIPER, GUWAHATI conducts research in different areas of pharmaceutical sciences keeping in view the national and local needs.

Department of Biotechnology

Development of synthetic riboswitches to suppress gene expression in case of various life-threatening diseases.

Development of deoxyribozymes, which can degrade RNA of various oncogenes. Generation of various novel protein coding sequences, which can be further developed as biopharmaceuticals.

Suitability of G-quadruplexes as gene regulation tool in cancer and other diseases.

Directed evolution of therapeutic proteins for enhanced activity and least immunogenicity.

Study in the field of Molecular Hematology to observe the molecular details in various diseases like Multiple Myeloma, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Myodisplastic syndrome.

Molecular genomics and expression of various targets in Ischemia Stroke disorder etc.

Pharmacogenomics study in Diabetes, use of drugs like clopidogrel and its pharmacogenomic approaches.

Investigation in Molecular pathophysiology of various targets in Neuropathic pain and its future treatment.

Study in the field of Proteomics to develop various target drugs for therapeutic approaches.

Protective effect of Carissa carandas against cyclophosphamide-induced toxicity.

Evaluate the effect of Naringenin and Crocetin on cyclophosphamide-induced testicular toxicity.

Studies on anti-tumor activity of various plants available in the North East region Effect of Ocimum sanctum in experimental diabetic neuropathy.

Anti-inflammatory activity of Morabulus jalepa in acute and chronic models of inflammation in rats.

Effect of Green tea polyphenols on the pharmacokinetics of Paclitaxel

Evaluate anti-inflammatory activity of Hibiscus rosa sinensis in rats.

Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice.

Studies on Neurodegenerative diseases like Parkinson’s, Alzheimer’s etc.

Pharmacological studies of various anti cancer agents and plant extracts.

Pharmacological studies in depression.

Department of Pharmacy Practice

Adverse Drug Reaction (ADR) monitoring

Drug Drug Interaction (DDI) studies

Drug utilization

Pharmacovigilance studies

ADR monitoring of Anti-TB therapy

Research at NIPER-Guwahati

2015

  • "Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice." Ali SH, Madhana RM, K V A, Kasala ER, Bodduluru LN, Pitta S, Mahareddy JR, Lahkar M. Steroids. 2015 Jun 3;101:37-42.
  • Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus. Jangra A, Kasbe P, Pandey SN, Dwivedi S, Gurjar SS, Kwatra M, Mishra M, Venu AK, Sulakhiya K, Gogoi R, Sarma N, Bezbaruah BK, Lahkar M. Biol. Trace Elem. Res. 2015 May 28.
  • Mangiferin ameliorates aluminium chloride-induced cogniti"e dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level. Kasbe P, Jangra A, Lahkar M. J. Trace Elem. Med. Biol. 2015 Jul;31:107-12.
  • "Chrysin and its emerging role in cancer drug resistance.” Kasala ER, Bodduluru LN, Barua CC, Gogoi R. Chem. Biol. Interact. 2015 Jul 5;236:7-8.
  • "Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice." Sriram CS, Jangra A, Gurjar SS, Hussain MI, Borah P, Lahkar M, Mohan P, Bezbaruah BK. Pharmacol Biochem Behav. 2015 Jun;133:83-91.
  • "Multiple facets of poly(ADP-ribose) polymerase-1 in neurological diseases." Sriram CS, Jangra A, Madhana RM, Gurjar SS, Mohan P, Bezbaruah BK. Neural Regen Res. 2015 Jan;10(1):49-51.
  • "Beneficial effect of honokiol on lipopolysaccharide induced anxiety-like behavior and liver damage in mice." Sulakhiya K, Kumar P, Gurjar SS, Barua CC, Hazarika NK. Pharmacol Biochem Behav. 2015 Feb 26;132:79-87.
  • "Evaluation of antitumor activity and antioxidant status of Alternanthera brasiliana against Ehrlich ascites carcinoma in Swiss albino mice." Samudrala PK, Augustine BB, Kasala ER, Bodduluru LN, Barua C, Lahkar M. Pharmacognosy Res. 2015 Jan-Mar;7(1):66-73.
  • "Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives." Kasala ER, Bodduluru LN, Madana RM, V AK, Gogoi R, Barua CC. Toxicol Lett. 2015 Mar 4;233(2):214-25.
  • "Natural killer cells: the journey from puzzles in biology to treatment of cancer." Bodduluru LN, Kasala ER, Madhana RM, Sriram CS. Cancer Lett. 2015 Feb 28;357(2):454-67.

2014

  • "Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice." Sulakhiya K, Kumar P, Jangra A, Dwivedi S, Hazarika NK, Baruah CC, Lahkar M. Eur J Pharmacol. 2014 Dec 5;744:124-31.
  • "Effects of Cleome viscosa on hyperalgesia, oxidative stress and lipid profile in STZ induced diabetic neuropathy in Wistar rats." Rao BS, Reddy KE, Parveen K, Narendra BL, Shekhar SC, Mangala L. Pak J. Pharm. Sci. 2014 Sep;27(5):1137-45.
  • "Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice." Jangra A, Lukhi MM, Sulakhiya K, Baruah CC, Lahkar M. Eur J Pharmacol. 2014 Oct 5;740:337-45.
  • "Targeting poly(ADP-ribose)polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation." Sriram CS, Jangra A, Kasala ER, Bodduluru LN, Bezbaruah BK. Neurochem Int. 2014 Oct;76:70-81.
  • "Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms." Bodduluru LN, Kasala ER, Thota N, Barua CC, Sistla R. Toxicol In Vitro. 2014 Aug;28(5):1026-35.
  • "Protein folding and misfolding in the neurodegenerative disorders: a review". Bolshette NB, Thakur KK, Bidkar AP, Trandafir C, Kumar P, Gogoi R. Rev Neurol (Paris). 2014 Mar;170(3):151-61.

2013

  • Eshvendar Reddy Kasala, Bodduluru Lakshmi Narendra, Yogeshwar Maneti and Rajesh Thipparaboina. "Effect of meditation on neurophysiological changes in stress mediated depression." Complementary Therapies in Clinical Practice (2013).
  • Jay R. Anand, Harish Rijhwani, Kanakadurga Malapati, Parveen Kumar, Kandarpa Saikia, Mangala Lakhar. Anticancer activity of esculetin via-modulation of Bcl-2 and NF-?B expression in benzo[a]pyrene induced lung carcinogenesis in mice. Biomedicine & Preventive Nutrition; Volume 3, Issue 2, April–June 2013, Pages 107-112.
  • Parveen Kumar, Nityanand B. Bolshette, Vinayak S. Jamdade, Nitin A. Mundhe, Krishan K. Thakur, Kandrapa K. Saikia, Mangala Lahkar. Breast cancer status in India: An overview. Biomedicine & Preventive Nutrition; Volume 3, Issue 2, April–June 2013, Pages 177-183.
  • Parveen Kumar, Krishna Shastrula Prashanth, Anil Bhanudas Gaikwad, Mohit Vij, Chandana C. Barua, Babul Bezbaruah.Disparity in actions of rosiglitazone against cisplatin-induced nephrotoxicity in female Sprague-Dawley rats. Environmental Toxicology and Pharmacology, Volume 36, Issue 3, November 2013, Pages 883-890.
  • Parveen Kumar, Sonu Kumar, Chandana C. Barua. Breast cancer management. Biomed Pharmacol: 2013; In press corrected proof.
  • Boddapati Srinivasa Rao, Kasala Eshvendar Reddy, Kumar Parveen, Bodduluru Lakshmi Narendra, Sriram Chandra Shaker, Lahkar Mangala. Effects of Cleome viscosa on hyperalgesia, oxidative stress and lipid profile in STZ induced diabetic neuropathy in Wistar rats. Pakistan Journal of Pharmaceutical Sciences. 2013, Accepted Manuscript
  • Tiwari S, Lahkar M, Dash S, Samudrala PK, Thomas JM, Augustine BB. Preliminary phytochemical, Toxicity and Anti-inflammatory Evaluation of Commelina benghalensis. International Journal of Green Pharmacy 2013; 7(3).
  • Augustine BB, Dash S, Lahkar M, Sarma U, Samudrala PK, Thomas JM. Leucas aspera inhibits the Dalton’s ascitic lymphoma in Swiss albino mice: A preliminary study exploring possible mechanism of action. Pharmacognosy Magazine 2013.
  • Pitta S, Augustine BB, Reddy EJ, Sulakhiya KB, Killi R, Lahkar M. Honokiol reverses depressive-like behavior and decrease brain BDNF levels induced by chronic corticosterone injections in mice. Pharmacognosy Journal 2013.
  • Bibin Baby Augustine, Suvakanta Dash, Mangala Lahkar, Ratan J Lihite, Pavan Kumar Samudrala, Sathish Pitta. Effect of mirabilis jalapa flowers in experimentally induced arthritis and consecutive oxidative stress. International Journal of Pharmacy and Pharmaceutical Sciences; 2013, Volume 5, Issue 2, 190-193.
  • Bhaskarjyoti Dutta, Mangala Lahkar, Bibin Baby Augustine, Ratan J. Lihite. Hepatoprotective activity of tamarind indica and homalomena aromatica in rats. International Journal of Pharmacy and Pharmaceutical Sciences; 2013, Volume 5, Issue 2, 436-438.
  • Sriram Chandra Shaker, Lahkar Mangala, Kasala Eshvendar Reddy. Evaluation of anxiolytic activity of sesamol in swiss albino mice. American Journal of Pharmatech Research; 2013; 3 (2), 768-777.
  • AV Kiran Reddy, Ratan J. Lihite, Mangala Lahkar, Urmi Choudhury, Swaroop K. Baruah. A Study on Adverse Drug Reactions in HIV Infected Patients at a ART Centre of Tertiary Care Hospital in Guwahati, India Asian Journal of Pharmaceutical and Clinical Research. May 2013.

2011-10

  • A Review on Cancer Vaccines, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- Vinodh Jaganti, Sukirti Das, T. Sai Sampath.
  • A Review on Ankylosing Spondylitis, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- V. Santhosh Kumar, Sukirti Das, T.Sai Sampath.
  • Role of Peroxynitrite in Diabetic Neuropathy: Peroxynitrite Decomposition Catalysts, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- Sampath Kumar.V, Lingesh.A, Bhaskar.B, Upender.A.
  • Anxiolytic Effect of Ethanolic Extract of Oxalis Corniculata .L in Mice, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- Sai Sampath. T, Santosh.P, Mangala Lahkar, Ajaygodwin.P, Pavan Kumar.S and Lingesh.A.
  • Review on Plant Derived Natural Products and Their Analogues with Chemo protective Activity against Genotoxicity of Cyclophosphamide, Ijpbs, Vol2, Issue3, Jul-Sept 201 -- Sai Sampath.T, Kanaka Durga. M, Saranya. BH, Kalyani.K.
  • Assessment of Drug Therapy in Geriatric Patients Using Beer’s Criteria, Journal of the Indian Academy of Geriatrics, Dec 2010 Issue, Vol 6, No: 4. -- Ratan J Lihite, Mangala Lahkar.
  • Antidepressant Activity of Methanolic Extract of Passifora foetida Leaves in Mice Santosh.P -- Dr.Mangala Lahkar, Venugopal.R, Nilakash As, Kunjbihari.S.

Projects going on @ NIPER-Guwahati

Currently three projects are going on at NIPER-Guwahati

  • DST WOS-A Project (Principal investigator - Dr. Swapnil Sinha, Mentor - Dr. Utpal Mohan)
    Drug-resistant bacteria are a growing challenge to world health, and new approaches to antibiotic development are needed. Riboswitches, which are regulatory elements of mRNA, are shown to be a potential new target for antibiotic drugs. We are highly interested in developing a riboswitch-based toolbox to target and study infectious diseases like tuberculosis. Riboswitches are structures that form in mRNA and regulate gene expression after binding to ligands. 5’ untranslated region (5’ UTR) of mRNA which refers to the region between the transcriptional and the translational start sites, in the presence of a specific ligand, folds in such a way that it up-regulates or down-regulates the gene expression and hence the name riboswitch that could be turned ON and OFF. We are using this strategy to identify lead molecules, which binds to the 5’ UTR of genes crucial for pathogenesis/survival of Mycobacterium tuberculosis and inhibit the expression of downstream gene thus abrogating the manifestations of tuberculosis.
  • DBT Twinning Project (NIPER-Guwahati and NIPER-Hyderabad) - (PI - Dr. Ranadeep Gogoi, Co PI - Dr. (Mrs) Mangala Lahkar)
    Neuropathic pain is a complex problem, differing in its aetiologies. The currently available pharmacotherapies exert variable and limited efficacy depending on the type of neuropathic pain state present and are associated with significant adverse-effect profiles. Neuropathic pain, according to NeuPSIG (Special Interest Group on Neuropathic Pain) definition, is the pain resulting from a lesion or disease affecting the somatosensory system]. It affects as much as 5% of the worldwide population with conditions like diabetic neuropathy, post herpetic neuralgia, neuropathy associated with stroke, multiple sclerosis, HIV infection, traumatic injury, alcoholism, cancer and chemotherapy. This project may provide an insight to design and develop futuristic treatment regimen for neuropathic pain. This study may help to identify the role of neuroinflammatory and oxidative-nitrosative stress related PARP overactivation in the pathophysiology of neuropathic pain. This may further enable to provide newer combination therapies that not only alleviate the neuropathic pain but it also attenuates the nerve damage and prevent further progression of neuropathic pain and neurodegenerative mechanism.
  • DBT-Institutional Level Biotech Hub (Coordinator: Dr. Mangala Lahkar, CAC, NIPER-Guwahati)
    This project is sponsored by the Department of Biotechnology, Govt. of India, for the establishment of an Institutional Biotechnology Hub, which can promote scientific growth aided by the facilities like advanced instrumentation and other resources.

Research Collaborations of NIPER-Guwahati

NIPER-Guwahati in its endeavour to become a centre of excellence, intend to collaborate with various academic and research institutes of the country.

NIPER-Guwahati signed MoU with a number of Research as well as academic Institutes of repute viz.,