Research at NIPER-Guwahati

NIPER, GUWAHATI conducts research in different areas of pharmaceutical sciences keeping in view the national and local needs.

Department of Biotechnology

Molecular genomics and expression of various targets in Ischemia Stroke disorder etc.

Pharmacogenomics study in Diabetes, use of drugs like clopidogrel and its pharmacogenomic approaches.

Investigation in Molecular pathophysiology of various targets in Neuropathic pain and its future treatment.

Study in the field of Proteomics to develop various target drugs for therapeutic approaches.

Development of synthetic riboswitches to suppress gene expression in case of various life-threatening diseases.

Development of deoxyribozymes, which can degrade RNA of various oncogenes. Generation of various novel protein coding sequences, which can be further developed as biopharmaceuticals.

Suitability of G-quadruplexes as gene regulation tool in cancer and other diseases.

Directed evolution of therapeutic proteins for enhanced activity and least immunogenicity.

Department of Pharmacology and Toxicology

Study in the field of Molecular Hematology to observe the molecular details in various diseases like Multiple Myeloma, Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Myodisplastic syndrome.

Protective effect of Carissa carandas against cyclophosphamide-induced toxicity.

Evaluate the effect of Naringenin and Crocetin on cyclophosphamide-induced testicular toxicity.

Studies on anti-tumor activity of various plants available in the North East region Effect of Ocimum sanctum in experimental diabetic neuropathy.

Anti-inflammatory activity of Morabulus jalepa in acute and chronic models of inflammation in rats.

Effect of Green tea polyphenols on the pharmacokinetics of Paclitaxel

Evaluate anti-inflammatory activity of Hibiscus rosa sinensis in rats.

Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice.

Studies on Neurodegenerative diseases like Parkinson’s, Alzheimer’s etc.

Pharmacological studies of various anti cancer agents and plant extracts.

Pharmacological studies in depression.

Department of Pharmacy Practice

Adverse Drug Reaction (ADR) monitoring

Drug Drug Interaction (DDI) studies

Drug utilization

Pharmacovigilance studies

ADR monitoring of Anti-TB therapy

Department of Pharmaceutical Analysis

Analytical and bioanalytical method development and validation

Pharmacokinetic studies of drugs and metabolites

Identification and characterization of impurities in drug substances

Forced degradation studies and characterization of degradation products

Short-term/accelerated, mid-term and long-term stability testing of formulations

Pre-formulation (physicochemical parameters & excipient compatibility) studies

Chemical characterization of biomarkers in herbal products

Department of Pharmaceutics

Preformulation studies

Dosage form development and optimization for poorly water soluble drug molecules

Drug targeting using ligand anchored lipid-and polymer-based nanoarchitectonics

Micro-and nano-theragnosis concepts for the early detection and treatment of malignant diseases and other life-threatening diseases

Eradication of biofilm-producing microorganisms from the surfaces of implanted or inserted medical devices into human body

Pharmacoengineering, molecular pharmaceutics, biopharmaceutics & pharmacokinetics

Drug-in-adhesive matrix/reservoir type transdermal drug delivery systems

Organ & lymphatic delivery of nanomedicines along with deep molecular insights

Translational cutting-edge biomedical research and biomaterials fabrication.

Publications at NIPER-Guwahati

2015

  • "Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice." Ali SH, Madhana RM, K V A, Kasala ER, Bodduluru LN, Pitta S, Mahareddy JR, Lahkar M. Steroids. 2015 Jun 3;101:37-42.
  • Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus. Jangra A, Kasbe P, Pandey SN, Dwivedi S, Gurjar SS, Kwatra M, Mishra M, Venu AK, Sulakhiya K, Gogoi R, Sarma N, Bezbaruah BK, Lahkar M. Biol. Trace Elem. Res. 2015 May 28.
  • Mangiferin ameliorates aluminium chloride-induced cogniti"e dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level. Kasbe P, Jangra A, Lahkar M. J. Trace Elem. Med. Biol. 2015 Jul;31:107-12.
  • "Chrysin and its emerging role in cancer drug resistance.” Kasala ER, Bodduluru LN, Barua CC, Gogoi R. Chem. Biol. Interact. 2015 Jul 5;236:7-8.
  • "Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice." Sriram CS, Jangra A, Gurjar SS, Hussain MI, Borah P, Lahkar M, Mohan P, Bezbaruah BK. Pharmacol Biochem Behav. 2015 Jun;133:83-91.
  • "Multiple facets of poly(ADP-ribose) polymerase-1 in neurological diseases." Sriram CS, Jangra A, Madhana RM, Gurjar SS, Mohan P, Bezbaruah BK. Neural Regen Res. 2015 Jan;10(1):49-51.
  • "Beneficial effect of honokiol on lipopolysaccharide induced anxiety-like behavior and liver damage in mice." Sulakhiya K, Kumar P, Gurjar SS, Barua CC, Hazarika NK. Pharmacol Biochem Behav. 2015 Feb 26;132:79-87.
  • "Evaluation of antitumor activity and antioxidant status of Alternanthera brasiliana against Ehrlich ascites carcinoma in Swiss albino mice." Samudrala PK, Augustine BB, Kasala ER, Bodduluru LN, Barua C, Lahkar M. Pharmacognosy Res. 2015 Jan-Mar;7(1):66-73.
  • "Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives." Kasala ER, Bodduluru LN, Madana RM, V AK, Gogoi R, Barua CC. Toxicol Lett. 2015 Mar 4;233(2):214-25.
  • "Natural killer cells: the journey from puzzles in biology to treatment of cancer." Bodduluru LN, Kasala ER, Madhana RM, Sriram CS. Cancer Lett. 2015 Feb 28;357(2):454-67.

2014

  • "Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice." Sulakhiya K, Kumar P, Jangra A, Dwivedi S, Hazarika NK, Baruah CC, Lahkar M. Eur J Pharmacol. 2014 Dec 5;744:124-31.
  • "Effects of Cleome viscosa on hyperalgesia, oxidative stress and lipid profile in STZ induced diabetic neuropathy in Wistar rats." Rao BS, Reddy KE, Parveen K, Narendra BL, Shekhar SC, Mangala L. Pak J. Pharm. Sci. 2014 Sep;27(5):1137-45.
  • "Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice." Jangra A, Lukhi MM, Sulakhiya K, Baruah CC, Lahkar M. Eur J Pharmacol. 2014 Oct 5;740:337-45.
  • "Targeting poly(ADP-ribose)polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation." Sriram CS, Jangra A, Kasala ER, Bodduluru LN, Bezbaruah BK. Neurochem Int. 2014 Oct;76:70-81.
  • "Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms." Bodduluru LN, Kasala ER, Thota N, Barua CC, Sistla R. Toxicol In Vitro. 2014 Aug;28(5):1026-35.
  • "Protein folding and misfolding in the neurodegenerative disorders: a review". Bolshette NB, Thakur KK, Bidkar AP, Trandafir C, Kumar P, Gogoi R. Rev Neurol (Paris). 2014 Mar;170(3):151-61.

2013

  • Eshvendar Reddy Kasala, Bodduluru Lakshmi Narendra, Yogeshwar Maneti and Rajesh Thipparaboina. "Effect of meditation on neurophysiological changes in stress mediated depression." Complementary Therapies in Clinical Practice (2013).
  • Jay R. Anand, Harish Rijhwani, Kanakadurga Malapati, Parveen Kumar, Kandarpa Saikia, Mangala Lakhar. Anticancer activity of esculetin via-modulation of Bcl-2 and NF-?B expression in benzo[a]pyrene induced lung carcinogenesis in mice. Biomedicine & Preventive Nutrition; Volume 3, Issue 2, April–June 2013, Pages 107-112.
  • Parveen Kumar, Nityanand B. Bolshette, Vinayak S. Jamdade, Nitin A. Mundhe, Krishan K. Thakur, Kandrapa K. Saikia, Mangala Lahkar. Breast cancer status in India: An overview. Biomedicine & Preventive Nutrition; Volume 3, Issue 2, April–June 2013, Pages 177-183.
  • Parveen Kumar, Krishna Shastrula Prashanth, Anil Bhanudas Gaikwad, Mohit Vij, Chandana C. Barua, Babul Bezbaruah.Disparity in actions of rosiglitazone against cisplatin-induced nephrotoxicity in female Sprague-Dawley rats. Environmental Toxicology and Pharmacology, Volume 36, Issue 3, November 2013, Pages 883-890.
  • Parveen Kumar, Sonu Kumar, Chandana C. Barua. Breast cancer management. Biomed Pharmacol: 2013; In press corrected proof.
  • Boddapati Srinivasa Rao, Kasala Eshvendar Reddy, Kumar Parveen, Bodduluru Lakshmi Narendra, Sriram Chandra Shaker, Lahkar Mangala. Effects of Cleome viscosa on hyperalgesia, oxidative stress and lipid profile in STZ induced diabetic neuropathy in Wistar rats. Pakistan Journal of Pharmaceutical Sciences. 2013, Accepted Manuscript
  • Tiwari S, Lahkar M, Dash S, Samudrala PK, Thomas JM, Augustine BB. Preliminary phytochemical, Toxicity and Anti-inflammatory Evaluation of Commelina benghalensis. International Journal of Green Pharmacy 2013; 7(3).
  • Augustine BB, Dash S, Lahkar M, Sarma U, Samudrala PK, Thomas JM. Leucas aspera inhibits the Dalton’s ascitic lymphoma in Swiss albino mice: A preliminary study exploring possible mechanism of action. Pharmacognosy Magazine 2013.
  • Pitta S, Augustine BB, Reddy EJ, Sulakhiya KB, Killi R, Lahkar M. Honokiol reverses depressive-like behavior and decrease brain BDNF levels induced by chronic corticosterone injections in mice. Pharmacognosy Journal 2013.
  • Bibin Baby Augustine, Suvakanta Dash, Mangala Lahkar, Ratan J Lihite, Pavan Kumar Samudrala, Sathish Pitta. Effect of mirabilis jalapa flowers in experimentally induced arthritis and consecutive oxidative stress. International Journal of Pharmacy and Pharmaceutical Sciences; 2013, Volume 5, Issue 2, 190-193.
  • Bhaskarjyoti Dutta, Mangala Lahkar, Bibin Baby Augustine, Ratan J. Lihite. Hepatoprotective activity of tamarind indica and homalomena aromatica in rats. International Journal of Pharmacy and Pharmaceutical Sciences; 2013, Volume 5, Issue 2, 436-438.
  • Sriram Chandra Shaker, Lahkar Mangala, Kasala Eshvendar Reddy. Evaluation of anxiolytic activity of sesamol in swiss albino mice. American Journal of Pharmatech Research; 2013; 3 (2), 768-777.
  • AV Kiran Reddy, Ratan J. Lihite, Mangala Lahkar, Urmi Choudhury, Swaroop K. Baruah. A Study on Adverse Drug Reactions in HIV Infected Patients at a ART Centre of Tertiary Care Hospital in Guwahati, India Asian Journal of Pharmaceutical and Clinical Research. May 2013.

2011-10

  • A Review on Cancer Vaccines, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- Vinodh Jaganti, Sukirti Das, T. Sai Sampath.
  • A Review on Ankylosing Spondylitis, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- V. Santhosh Kumar, Sukirti Das, T.Sai Sampath.
  • Role of Peroxynitrite in Diabetic Neuropathy: Peroxynitrite Decomposition Catalysts, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- Sampath Kumar.V, Lingesh.A, Bhaskar.B, Upender.A.
  • Anxiolytic Effect of Ethanolic Extract of Oxalis Corniculata .L in Mice, Ijpbs, Vol2, Issue3, Jul-Sept 2011 -- Sai Sampath. T, Santosh.P, Mangala Lahkar, Ajaygodwin.P, Pavan Kumar.S and Lingesh.A.
  • Review on Plant Derived Natural Products and Their Analogues with Chemo protective Activity against Genotoxicity of Cyclophosphamide, Ijpbs, Vol2, Issue3, Jul-Sept 201 -- Sai Sampath.T, Kanaka Durga. M, Saranya. BH, Kalyani.K.
  • Assessment of Drug Therapy in Geriatric Patients Using Beer’s Criteria, Journal of the Indian Academy of Geriatrics, Dec 2010 Issue, Vol 6, No: 4. -- Ratan J Lihite, Mangala Lahkar.
  • Antidepressant Activity of Methanolic Extract of Passifora foetida Leaves in Mice Santosh.P -- Dr.Mangala Lahkar, Venugopal.R, Nilakash As, Kunjbihari.S.

Projects going on @ NIPER-Guwahati

TITLE PI/CO-PI FUNDING AGENCY APPROVED FUND APPROVED YEAR
Himalayan Fellowship Proposal for NMHS Grant PI - Dr. USN Murty
Co-PI - Dr. VGM Naidu
Ministry of Environment & Forestry 127 Lakhs 2018
Systematic and Scientific investigation of selected medicinal plants from north eastern part of India for rheumatoid arthritis and derivation of mechanism of action using bioguided fractionation methods besides identification and characterization of lead molecules using liquid-liquid separation technique. PI - Dr. USN Murty
Co-PI - Dr. VGM Naidu
DBT-NE 55.76 Lakhs 2018
Gold Capsuled Combination Nanomedicine for Target Specic Therapy of Chemoresistant Breast Tumors. Co-PI - Dr. VGM Naidu DST-SERB 12.65 Lakhs 2017
Prophylactic transdermal patch against neurotoxin poisoning in biological warfare situations. Co-PI - Dr. Subham Banerjee BIRAC-SRISTI GYTI Award, Dept. of Biotechnology (DBT), Govt. of India 15 Lakhs 2017
DBT Twinning Collaborative Project between NIPER-Guwahati & IITR-Lucknow. PI - Dr. Utpal Mohan DBT 48.10 Lakhs 2017
DBT-BioCARE PI - Dr. Shubhangi Kaushik DBT 43 Lakhs 2017
Design and Fabrication of EphA2 receptor targeting lipid polymer hybrid particles for sensitising breast cancer stem cells to enhance efficiency of chemotherapy. PI - Dr. VGM Naidu DST-SERB 11.10 Lakhs 2015
DBT Twinning Collaborative Project between NIPER-Guwahati & NIPER- Hyderabad. PI - Dr. Ranadeep Gogoi DBT 50.70 Lakhs 2014
DST-WOS-A Project PI - Dr. Swapnil Sinha
Mentor - Dr. Utpal Mohan
DST 30 Lakhs 2014